EUROPEAN COMMISSION AUTHORISES ViiV HEALTHCARE’S APRETUDE (CABOTEGRAVIR LONG-ACTING AND TABLETS) FOR HIV PREVENTION

  • Given as few as six times per year, cabotegravir has demonstrated superior efficacy to a daily oral PrEP option (FTC/TDF tablets) in reducing the risk of HIV acquisition in clinical trials.1,2,3,4
  • With approximately 100,000 people newly diagnosed with HIV each year in Europe,5 expanding HIV prevention options is crucial in reducing HIV transmission.

London, 19 September 2023 – ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer and Shionogi as shareholders, today announced that the European Commission has authorised Apretude (cabotegravir long-acting (LA) injectable and tablets) for HIV prevention. Cabotegravir is indicated in combination with safer sex practices for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection in high-risk adults and adolescents (at least 12 years of age), weighing at least 35 kg.

Cabotegravir LA injectable and tablets for PrEP is the first and only HIV prevention option approved in the European Union (EU) that reduces the number of doses needed for effective HIV prevention from 365 daily pills to as few as six injections per year. Cabotegravir LA injectable and tablets for PrEP has demonstrated superior efficacy to daily oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) in reducing the risk of HIV acquisition in clinical trials, giving people in the EU more options for PrEP.1,2,3,4

Link to original news to site

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We introduce a new visual style created by Noit, a development and design studio.

We introduce a new visual style created by Noit, a development and design studio.

As part of the “MSM Checkpoint EHPV” project, supported by the Elton John Foundation and the Estonian Network of People Living with HIV, we have developed a series of banners that inform about the important services provided by MSM EHPV checkpoints in Estonia.

Furthermore, in the near future, we will be pleased to present an informational resource dedicated to HIV prevention before and after potential exposure (PrEP and PEP) as well as an animated video about the operations of MSM checkpoints in Estonia.

The foundation of our concept is to encourage men engaging in sexual relationships with men to prioritize their health and take care of their partners’ health. We emphasize the importance of testing and treatment, the use of PrEP and PEP, access to condoms, and the provision of information and support.

This project aims to have a significant impact on the MSM community in Estonia, promoting a healthier lifestyle and HIV prevention.

Cell reports medicine

Highlights

  • Venetoclax delays viral rebound in a humanized mouse model of HIV infection
  • Venetoclax depletes intact HIV DNA ex vivo in cells from people living with HIV on ART
  • The HIV reservoir is enriched in cells with higher expression of BH3-only proteins

Summary

HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a humanized mouse model of HIV-1 infection and CD4+ T cells from PLWH on ART, we investigate whether antagonizing host pro-survival proteins can prime latent cells to die and facilitate HIV-1 clearance. Venetoclax, a pro-apoptotic inhibitor of Bcl-2, depletes total and intact HIV-1 DNA in CD4+ T cells from PLWH ex vivo. This venetoclax-sensitive population is enriched for cells with transcriptionally higher levels of pro-apoptotic BH3-only proteins. Furthermore, venetoclax delays viral rebound in a mouse model of persistent HIV-1 infection, and the combination of venetoclax with the Mcl-1 inhibitor S63845 achieves a longer delay in rebound compared with either intervention alone. Thus, selective inhibition of pro-survival proteins can induce death of HIV-1-infected cells that persist on ART, extending time to viral rebound.

Graphical abstract

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Introducing the Baltic Refugee Support Hub!

🌟 Introducing the Baltic Refugee Support Hub! 🌍🤝

In the wake of russian aggression and invasion of Ukraine in 2022, a wave of refugees found their way to the shores of Europe, seeking safety and solace. The numbers were staggering – over 8 million refugees across Europe, with more than 500,000 finding refuge in the Baltic and Nordic regions, of which 1/3 were innocent children, and number of key populations representatives from Ukraine.

Amidst this challenge, a beacon of hope emerged – the Baltic Refugee Support Hub, brought to life by the tireless efforts of the NGO Estonian Network of People living with HIV. Operating from June 2023 to October 2024, this project aims to extend a helping hand to those in need and reshape their lives.

🤝 Partnership for Progress

Working shoulder to shoulder with AGIHAS in Latvia, Positiiviset ry and HivFinland in Finland, EHPV in Estonia, and planning to expand to Lithuania Norway, the Baltic Hub seeks to unite hearts and resources across borders. A powerful memorandum of understanding will be signed, setting the stage for a collective mission.

🏠 The Baltic Hub – supporting Ukrainian refugees

The Baltic Hub is more than a project – it’s a lifeline for those who’ve endured the hardships of war. It provides a central point of coordination for services spanning psycho-social, medical, socio-economic, legal, and informational realms. This refuge of support is open to Ukrainian refugees living with HIV, the LGBT+ community, families impacted by HIV, children, and other key groups.

🌐 A Compassionate Connection

Within the frames of activities we`re proud to announce that the multilingual website will be launched, designed to guide refugees in their journey toward better lives. This online portal, will be available in 7 languages, arming refugees with the information they need, directing them to the services available in their new countries. It’s a digital bridge to brighter tomorrows for those in need.

💬 Spreading the Message

The Baltic Hub isn’t just about infrastructure – it’s about ensuring every person who needs help can find it. Through a strategic communication campaign, we will be reaching out to Ukrainian AIDS centers, friendly family doctors, and NGOs working with key groups. Together, we will be promoting the website as a beacon of assistance, a lifeline for those seeking refuge in Baltic Countries.

🌟 Shaping a Sustainable Future

The journey doesn’t end with this project. A grand online conference will convene at the project’s close, sharing lessons learned and casting a vision for the Baltic Hub beyond these initial steps. It’s about building bridges that stand the test of time, offering hope to those in search of a brighter future.

🌍 Impact Beyond Borders

Join us in making a real impact. Together, we’re fostering increased welfare for war refugees – from HIV-positive individuals and their families to children and the LGBT+ community. With the Baltic Hub, an international informational service provision mechanism, we’re shaping a future where compassion knows no bounds.

🤝 Partners:

The Baltic Refugees Support HUB project is supported by Nordic Council of Ministers.

In country Partners are: AGIHAS, Latvia | Positiiviset ry, HivFinland, Finland | EHPV, Estonia | Demetra, Lithuania and others

Let’s change lives, one step at a time.

#BalticRefugeeSupportHub #StrongerTogether

2023 UNAIDS GLOBAL AIDS UPDATE RAPORT

Eкскурсія групи з України до Морського музею

Сьогодні відбулася екскурсія групи з України до Морського музею. За підтримки Pagulasabi

Пізнавальна, чаруюча та захоплююча! Це про екскурсію нашої групи до Морського музею. Скільки приємних вражень від побаченого та почутого від екскурсовода! Море, кораблі, старовинний маяк наче частина колодязя, пришвартований криголам. А в приміщенні музею наші враження набули ще більших емоцій. Історичні факти, експонати часів давнини та сучасності – все це заворожувало нас. Дуже цікаво було знаходитися в підводному човні Лембіт, уявити себе членом екіпажу. Також нам пощастило відвідати унікальну експозицію з Венеції, на якій ми почули про саме місто: його історію та сьогодення. А ще дізналися, як справжня гондола опинилася в музеї. Кожен бажаючий міг зробити фото в масці на прогулянці гондолою. А різні пристрої, імітатори підводного плавання, польоту на повітряній кулі, карети та багато іншого подарували дітям масу чудових вражень. Трохи стомлені, але дуже задоволені, ми прийшли до кафе, де нас почастували смачним обідом. За столом ділилися тим, що більше всього вразило. Адже ми побували в одному з найбільших музеїв Естонії. Від учасників цієї екскурсії висловлюємо велику подяку всім, хто її організував. Тому що життя продовжується…

Summer School on Migrant Health in Eastern Europe and Central Asia

The work of EHPV and Baltic HUB were presented as best practices during “Summer School on Migrant Health in Eastern Europe and Central Asia”.

We had the incredible opportunity to participate in the “Summer School on Migrant Health in Eastern Europe and Central Asia” held in Yerevan, Armenia on August 21-22, 2023. This event, organized by Regional Expert Group on Migration and Health (REG) was aimed to delve into demographic and sociological research methods, focusing on assessing the health needs of displaced individuals, migrants, and refugees in the EECA region, as well as on discussing the best practices and the package of services for Migrants in EECA.

We had the privilege to present our work during session focusing on “Best Practices for Serving Key Groups Among Migrants and Refugees.” The project Manager of EHPV – Armen Aghajanov showcased the remarkable work of BALTIC HUB and EHPV in supporting refugees from Ukraine, especially those from the HIV+ and LGBT communities.
BALTIC HUB is a regional coordination center that unites HIV and LGBT organizations in Estonia, Latvia, Lithuania, and Finland. Their services include access to medicines, social support, health insurance consultation, psychological aid, and more. They’re expanding to include Norway, Poland, and Ukraine.

We are immensely grateful for this opportunity to present such a transformative initiative. The Summer School showcased the power of collaboration and innovation in addressing healthcare challenges among migrants. Let’s continue working together for a healthier and more inclusive future! 💪

#MigrantHealth #BALTICHUB #SummerSchool2023 #HealthcareForAll

CONGRATULATIONS ON THE DAY OF RESTORATION OF INDEPENDENCE OF Estonia!

CONGRATULATIONS ON THE DAY OF RESTORATION OF INDEPENDENCE OF Estonia! #ehpv #ehpv18 #Elagu Eesti!

 

HIV statistics

2023. As of 16 August, 99 people have been diagnosed with HIV in Estonia.

Over the years, 10,681 people have been diagnosed with HIV in Estonia.

https://www.terviseamet.ee/et/nakkushaigused-menuu/tervishoiutootajale/nakkushaigustesse-haigestumine/hiv-ja-aids

World Hepatitis Day 2023 ‘We’re not waiting’

Hepatitis B and C cause significantly higher cancer risk than smoking a daily pack of cigarettes
• World Hepatitis Day 2023 launches today with the urgent call to action ‘We’re not waiting’
• Nearly half (42%) of people globally are not aware that one of the leading
causes of liver cancer is viral hepatitis

Today, World Hepatitis Day (WHD) launches with the call to action ‘We’re not waiting.
A recent survey from WHA found that nearly half (42%) of people globally are unaware that one of the leading causes of liver cancer is viral hepatitis. Nearly three quarters (74%) of those surveyed say knowing hepatitis causes liver cancer means they are more likely to get tested and over four fifths (82%) say they are more likely to get vaccinated.
Globally, over 350 million people live with hepatitis B or C3, causing more than 1.1 million lives to be lost each year4. By 2040, deaths from viral hepatitis are expected to exceed mortality from HIV, malaria, and tuberculosis combined5.
Every year, more than a million lives are lost to hepatitis. The theme of World Hepatitis Day 2023 is ‘We’re not waiting’.
A new report from CDA Foundation finds that individuals living with hepatitis B
and C have a significantly higher risk of developing cancer than someone
smoking one pack of cigarettes per day1
New research presented at the EASL Congress by the Center for Disease Analysis (CDA)
Foundation1 found that hepatitis B (HBV) and C (HCV) viruses are highly oncogenic leading
to cancers in multiple organs and sites. The report finds that hepatitis B and C infected
individuals “have a similar or significantly higher risk of developing cancer than someone
who actively smokes one pack of cigarettes per day.” It concludes that HBV and HCV should
be “considered as cancer causing infections and international guidelines should be
reconsidered accordingly.”
It’s a call to accelerate elimination efforts of viral hepatitis now
and the urgent need for testing and treatment for the real people who need it. Individuals
and communities around the world are making change happen in their own lives and in world
around them. We celebrate them, while demanding more action.
change – we’re fighting to make it happen.”
“Hepatitis B and C infections are silent epidemics. These viral infections are cancer causing but since infected individuals don’t show any symptoms until it is too late, most infections go unnoticed. It is important for all of us to recognize the high risk of cancer associated with hepatitis B and C infection and get patients linked to care. Treatment can reduce the risk of cancer by 85% or more.”
We’re not waiting for
Get involved
World Hepatitis Alliance (WHA) have produced a range of multi-channel campaign resources that you can use to raise awareness in your communities and online. Download the campaign guidelines for more information on the visual identity, digital resources (also below in the ‘Digital assets’ section) and activations to get involved.
Download the campaign guidelines here.
Download the communications toolkit here.
For more information contact:
tajinder.tiwana@worldhepatitisalliance.org
Notes to editors:
About Viral Hepatitis
Viral hepatitis is inflammation of the liver caused by a virus. WHO say that the total deaths cause by viral hepatitis, including acute cases, cirrhosis and liver cancer account for 1.1 million deaths globally in 2019. There are five different hepatitis viruses – hepatitis A, B, C, D and E. Hepatitis A and E is spread mainly through ingestion of contaminated food and water and the disease is often endemic in countries with a lack of safe water and poor sanitation, but rarely becomes chronic. Hepatitis B is transmitted through contact with the blood or other bodily fluids of an infected person and approximately 296 million people are living with chronic infections. Hepatitis C is mainly spread through blood-to-blood contact such as unsafe injection practices and inadequate sterilisation of medical equipment. Today, 58 million people are living with the disease. Hepatitis D is passed on through contact with infected blood and only occurs in people who are already infected with hepatitis B.
In total over 350 million people in the world are living with viral hepatitis. Each year over a million people lose their lives because of conditions related to acute hepatitis and chronic infection that cause liver cancer and cirrhosis. Chronic hepatitis B and C infections are the leading cause of liver cancer
Despite there being a vaccine and effective treatment for hepatitis B and a cure for hepatitis C – few countries in the world are on track to achieve the WHO target of eliminating viral hepatitis by 2030 (Polaris Observatory – CDA Foundation).
About World Hepatitis Day
Held on July 28 each year, WHD is our day to raise awareness of viral hepatitis. On this day we aim to unite the global community to demand action from decision makers globally to prioritise the elimination of viral hepatitis. Across the world, campaign supporters will raise their voices on social media, hold webinars, speak to the media and hold events to spread the message and raise awareness of hepatitis.
WHD is one of the World Health Organization’s (WHO) officially mandated global public health days. It is a day when the world comes together to raise awareness of hepatitis, one of the most deadly and neglected diseases and health crises – one that is claiming a life every 30 seconds. Globally, 354 million people live with hepatitis, with more than 1.1 million lives lost each year to hepatitis B and hepatitis C. Yet, we have the tools to eliminate the disease by 2030.
Alongside this, WHD will also highlight the social injustice and inequity caused by the current lack of action on hepatitis elimination and focus on the positive action needed to get on track to meet our 2030 elimination goals.