Study of the project “Protection through Mobility: An Emergency Response to Hostility”


The project “Protection through Mobility: An Emergency Response to Hostility” was commissioned by the Estonian HIV-Positive Network
study on the implementation of humanitarian visa systems in the Member States of the European Union and the Schengen area.
A study has been ordered for this, with a file attached to it: EHPV_Study_Hum_Vis

HIV and Migration

1. Equal access to social medical services and uninterrupted HIV treatment for migrants in Estonia. As more and more people are coming to Estonia for work and study. For the last two years our organisation welcomed 30 migrants from different countries including HIV positive people and the representatives of vulnerable groups asking for support in getting social medical services as they were facing the following difficulties: 1 Access to medical services 2 Anxieties in terms of protecting confidentiality during the medical treatment 3 Language and cultural barriers 4 Access to testing, contraceptives, PReP and PEP, information on how to get the social medical services. Following its core mission and values, EHPV is providing full range of needed services. Connecting testing with treatment.

NGO Estonian Network of People Living with HIV wishes everyone a happy Valentine’s Day!

NGO Estonian Network of People Living with HIV wishes everyone a happy Valentine’s Day!

A highly virulent variant of HIV-1 circulating

Evolving virulence in HIV

Changes in viral load and CD4+ T cell decline are expected signals of HIV evolution. By examining data from well-characterized European cohorts, Wymant et al. report an exceptionally virulent subtype of HIV that has been circulating in the Netherlands for several years (see the Perspective by Wertheim). More than one hundred individuals infected with a characteristic subtype B lineage of HIV-1 were found who experienced double the rate of CD4+ cell count declines than expected. By the time they were diagnosed, these individuals were vulnerable to developing AIDS within 2 to 3 years. This virus lineage, which has apparently arisen de novo since around the millennium, shows extensive change across the genome affecting almost 300 amino acids, which makes it hard to discern the mechanism for elevated virulence. —CA

Abstract

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

Clinical trials of an experimental HIV vaccine based on Moderna’s mRNA technology have begun

FOTO: Taavi Sepp

Last week, Moderna reported that several people were vaccinated as part of the first phase of clinical trials of an experimental HIV vaccine based on mRNA technology, writes CNN.

The trial, called IAVI G002, is being conducted in collaboration with the non-profit research organization IAVI. These include testing a vaccine that delivers specific HIV antigens to the body in order to elicit an immune response. These antigens were developed by scientists at IAVI and Scripps Research led by Dr. William Schiff.

Last year, during the experimental proof-of-concept phase, the research team found that HIV antigens elicited the desired immune response in 97% of participants.

Based on the results of previous trials, scientists are testing the initial version of the vaccine, its booster version, as well as the implementation of Moderna’s mRNA technology, which was previously used to create a successful vaccine against COVID-19.

“We are incredibly excited to be able to advance a new direction in HIV vaccine development based on Moderna’s mRNA platform. The search for an HIV vaccine has been long and complex, and the availability of new tools—immunogens and platforms—could be the key to discovering a much-needed and effective HIV vaccine,” Mark Feinberg, President and CEO of IAVI, wrote in a Moderna press release.

The new trial, funded in part by the Bill & Melinda Gates Foundation, will involve 56 HIV-negative adults to study both the safety and efficacy of the vaccine. 48 volunteers will receive at least one dose of the primary vaccine, 32 of whom will receive a booster. Eight more people will receive only the booster vaccine.

Volunteers from the George Washington University School of Medicine, Hope Clinic, Emory Vaccine Center, Fred Hutchinson Cancer Research Center, and the University of Texas Health Sciences Center at San Antonio are participating in the trial.

Translated from Russian to English.

https://rus.delfi.ee/statja/95785515/nachalis-klinicheskie-ispytaniya-eksperimentalnoy-vakciny-protiv-vich-na-osnove-tehnologii-mrnk-ot-kompanii-moderna

Young sexual minority men and transgender women

Credit: Pixabay/CC0 Public Domain

About a fifth of young sexual minority males and transgender females are estimated to be engaging in transactional, or survival sex, according to results of a new survey study by Johns Hopkins Medicine researchers. The findings, which define the practice as trading sex for money, housing and other necessities (e.g., food, clothing), were published in the February 2022 issue of the Journal of Adolescent Health and first appeared online Jan. 16. The findings affirm that transactional sex may place young Black and Latinx gay or bisexual males and transgender females at risk for exposure to HIV.

“Previous studies have focused on transactional sex among young gay or bisexual males and transgender females, but few have tried to understand the prevalence among Black and Latinx youth in these groups,” says Johns Hopkins Children’s Center adolescent medicine specialist Renata Sanders, M.D., M.P.H., Sc.M. She is the study’s first author and an associate professor of pediatrics at the Johns Hopkins University School of Medicine

https://medicalxpress.com/news/2022-01-young-sexual-minority-men-transgender.html

Read more

Video: Believe and hope!

NGO Estonian Network of People Living with HIV presents: Believe and hope! Kaire Vilgats.Kayha Burns(USA) XXI Sajandi Orkester

HIV-positive diagnosed in Estonia in 2021 (27.01.2022)

As of January 27, 2022, 125 HIV-infected persons have been diagnosed in Estonia.

Over the years, a total of 10,350 people have been diagnosed with the HIV virus in Estonia.

https://www.terviseamet.ee/et/nakkushaigused-menuu/tervishoiutootajale/nakkushaigustesse-haigestumine/hiv-ja-aids

Information leaflets

“EHPV has developed information leaflets in Estonian, Russian and English, which introduce the possibilities of receiving help in case of a positive HIV diagnosis or suspicion of HIV. The information is aimed primarily at people who have come to Estonia from abroad to raise their awareness of the possibilities of receiving help in Estonia, but everyone who wants to be diagnosed with HIV or receive counseling can get information about the possibilities of testing and counseling. The information leaflets contains information about HIV counseling and testing offices across Estonia. ”

Information leaflets can be seen here:

Information leaflets for use on the web (in Estonian)

Information leaflets for use on the web (in English)

Information leaflets for use on the web (in Russian)

Information leaflets for printing (in Estonian)

Information leaflets for printing  (in English)

Information leaflets for printing  (in Russian)

 

A study on the implementation of humanitarian visa systems in the Member States of the European Union and the Schengen area was carried out as part of the project “Protection through Mobility: An Emergency Response to Hostility”.

A study on the implementation of humanitarian visa systems in the Member States of the European Union and the Schengen area has been carried out within the framework of the project “Protection through Mobility: An Emergency Response to Hostility” commissioned by the Estonian Network of HIV-positive People. The results of the survey were presented on October 20, 2021 and the survey was conducted by Liina Laanpere and Lehte Roots. ”

This study explored the legal framework and developments regarding humanitarian visas in the European Union, outlined and analysed practices of individual states, and developed recommendations for legislative amendments needed to implement a humanitarian visa system in Estonia.

After evaluating humanitarian visa schemes of different EU/Schengen states, Switzerland was identified as the best practice to follow. The Swiss system has most of the features recommended by the European Parliament in the 2018 Report with recommendations to the Commission on Humanitarian Visas147, and it is accessible for all asylum-seekers, including LGBTI+ asylum-seekers or HIV-positive asylum-seekers.

Read more